Catalytic N-Alkylation of Amines Using Carboxylic Acids and Molecular Hydrogen
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- 作者：Iv谩n Sorribes ; Jose R. Cabrero-Antonino ; Cristian Vicent ; Kathrin Junge ; Matthias Beller
- 刊名：Journal of the American Chemical Society
- 出版年：2015
- 出版时间：October 28, 2015
- 年：2015
- 卷：137
- 期：42
- 页码：13580-13587
- 全文大小：669K
- ISSN：1520-5126
文摘
A convenient, practical and green N-alkylation of amines has been accomplished by applying readily available carboxylic acids in the presence of molecular hydrogen. Applying an in situ formed ruthenium/triphos complex and an organic acid as cocatalyst, a broad range of alkylated secondary and tertiary amines are obtained in good to excellent yields. This novel method is also successfully applied for the synthesis of unsymmetrically substituted N-methyl/alkyl anilines through a direct three-component coupling reaction of the corresponding amines, carboxylic acids, and CO2 as a C1 source.