An Efficient Chitosan/Silica Composite Core–Shell Microspheres-Supported Pd Catalyst for Aryl Iodides Sonogashira Coupling Reactions

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• 作者：Qing Cui ; Hong Zhao ; Guangsheng Luo ; Jianhong Xu
• 刊名：Industrial & Engineering Chemistry Research
• 出版年：2017
• 出版时间：January 11, 2017
• 年：2017
• 卷：56
• 期：1
• 页码：143-152
• 全文大小：684K
• ISSN：1520-5045

文摘

Monodispersed chitosan/silica core–shell microspheres-supported Pd catalysts were prepared by a simple and affordable microfluidic device. Merely 5 mg of supported Pd catalyst (1 wt %) showed superior capability in Sonogashira coupling reactions between various aryl iodides and terminal alkynes in a mild environment (ligand-free, copper-free, amine-free, water–ethanol as solvent at 65 °C) even after eight cycles of use. These novel porous composite microspheres provide a new carrier to reduce the loading, enhance the activity, and increase the stability of noble metal catalyst.