The Discovery of Phthalazinone-Based Human H1 and H3 Single-Ligand Antagonists Suitable for Intranasal Administration for the Treatment of Allergic Rhinitis
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- 作者：Panayiotis A. Procopiou ; Christopher Browning ; Jennifer M. Buckley ; Kenneth L. Clark ; Lise Fechner ; Paul M. Gore ; Ashley P. Hancock ; Simon T. Hodgson ; Duncan S. Holmes ; Michael Kranz ; Brian E. Looker ; Karen M. L. Morriss ; Daniel L. Parton ; Linda J. Russell ; Robert J. Slack ; Steven L. Sollis ; Sadie Vile ; Clarissa J. Watts
- 刊名：Journal of Medicinal Chemistry
- 出版年：2011
- 出版时间：April 14, 2011
- 年：2011
- 卷：54
- 期：7
- 页码：2183-2195
- 全文大小：1157K
- 年卷期：v.54,no.7(April 14, 2011)
- ISSN：1520-4804
文摘
A series of potent phthalazinone-based human H1 and H3 bivalent histamine receptor antagonists, suitable for intranasal administration for the potential treatment of allergic rhinitis, were identified. Blockade of H3 receptors is thought to improve efficacy on nasal congestion, a symptom of allergic rhinitis that is currently not treated by current antihistamines. Two analogues (56a and 56b) had slightly lower H1 potency (pA2 9.1 and 8.9, respectively, vs 9.7 for the clinical gold-standard azelastine, and H3 potency (pKi 9.6 and 9.5, respectively, vs 6.8 for azelastine). Compound 56a had longer duration of action than azelastine, low brain penetration, and low oral bioavailability, which coupled with the predicted low clinical dose, should limit the potential of engaging CNS-related side-effects associated with H1 or H3 antagonism.