Lanthanide Phytanates: Liquid-Crystalline Phase Behavior, Colloidal Particle Dispersions, and Potential as Medical Imaging Agents

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• 作者：Charlotte E. Conn ; Venkateswarlu Panchagnula ; Asoka Weerawardena ; Lynne J. Waddington ; Danielle F. Kennedy ; Calum J. Drummond
• 刊名：Langmuir
• 出版年：2010
• 出版时间：May 4, 2010
• 年：2010
• 卷：26
• 期：9
• 页码：6240-6249
• 全文大小：993K
• 年卷期：v.26,no.9(May 4, 2010)
• ISSN：1520-5827

文摘

Lanthanide salts of phytanic acid, an isoprenoid-type amphiphile, have been synthesized and characterized. Elemental analysis and FTIR spectroscopy were used to confirm the formed product and showed that three phytanate anions are complexed with one lanthanide cation. The physicochemical properties of the lanthanide phytanates were investigated using DSC, XRD, SAXS, and cross-polarized optical microscopy. Several of the hydrated salts form a liquid-crystalline hexagonal columnar mesophase at room temperature, and samarium(III) phytanate forms this phase even in the absence of water. Select lanthanide phytanates were dispersed in water, and cryo-TEM images indicate that some structure has been retained in the dispersed phase. NMR relaxivity measurements were conducted on these systems. It has been shown that a particulate dispersion of gadolinium(III) phytanate displays proton relaxivity values comparable to those of a commercial contrast agent for magnetic resonance imaging and a colloidal dispersion of europium(III) phytanate exhibits the characteristics of a fluorescence imaging agent.