Absolute Configuration Determination Using Enantiomeric Pairs of Molecularly Imprinted Polymers

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• 作者：Danielle S. Meador ; David A. Spivak
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：March 7, 2014
• 年：2014
• 卷：16
• 期：5
• 页码：1402-1405
• 全文大小：292K
• 年卷期：v.16,no.5(March 7, 2014)
• ISSN：1523-7052

文摘

A new method for determination of absolute configuration (AC) is demonstrated using an enantiomeric pair of molecularly imprinted polymers, referred to as 鈥淒uoMIPs鈥? The ratio of HPLC capacity factors (k鈥? for the analyte on each of the DuoMIPs is defined as the 纬 factor and can be used to determine AC when above 1.2. A mnemonic based on the complementary binding geometry of the DuoMIPs was used to aid in understanding and prediction of AC.