The Development of a Manufacturing Route to an MCHr1 Antagonist
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- 作者：Michael Golden ; Danny Legg ; David Milne ; Arun Bharadwaj M. ; K. Deepthi ; Madan Gopal ; Nagaraju Dokka ; Sudhir Nambiar ; Puranik Ramachandra ; U. Santhosh ; Parhalad Sharma ; R. Sridharan ; Manjunatha Sulur ; Mats Linderberg ; Anders Nilsson ; Roger Sohlberg ; John Kremers ; Samuel Oliver ; Debasis Patra
- 刊名：Organic Process Research & Development
- 出版年：2016
- 出版时间：March 18, 2016
- 年：2016
- 卷：20
- 期：3
- 页码：675-682
- 全文大小：313K
- ISSN：1520-586X
文摘
Process development work to provide an efficient manufacturing route to a MCHr1 antagonist is presented herewith. Features of this development work include a scalable manufacturing route to the useful 6-oxa-2-azaspiro[3.3]heptane building block and the use of a (soluble) alternative to sodium triacetoxyborohydride.