Simple and Sensitive Paper-Based Device Coupling Electrochemical Sample Pretreatment and Colorimetric Detection
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- 作者：Thalita G. Silva ; William R. de Araujo ; Rodrigo A. A. Muñoz ; Eduardo M. Richter ; Mário H. P. Santana ; Wendell K. T. Coltro ; Thiago R. L. C. Paixão
- 刊名：Analytical Chemistry
- 出版年：2016
- 出版时间：May 17, 2016
- 年：2016
- 卷：88
- 期：10
- 页码：5145-5151
- 全文大小：402K
- 年卷期：0
- ISSN：1520-6882
文摘
We report the development of a simple, portable, low-cost, high-throughput visual colorimetric paper-based analytical device for the detection of procaine in seized cocaine samples. The interference of most common cutting agents found in cocaine samples was verified, and a novel electrochemical approach was used for sample pretreatment in order to increase the selectivity. Under the optimized experimental conditions, a linear analytical curve was obtained for procaine concentrations ranging from 5 to 60 μmol L–1, with a detection limit of 0.9 μmol L–1. The accuracy of the proposed method was evaluated using seized cocaine samples and an addition and recovery protocol.