Rhodium-Catalyzed Chemo- and Regioselective Decarboxylative Addition of β-Ketoacids to Allenes: Efficient Construction of Tertiary and Quaternary Carbon Centers

详细信息    查看全文

• 作者：Changkun Li ; Bernhard Breit
• 刊名：Journal of the American Chemical Society
• 出版年：2014
• 出版时间：January 22, 2014
• 年：2014
• 卷：136
• 期：3
• 页码：862-865
• 全文大小：314K
• ISSN：1520-5126

文摘

A rhodium-catalyzed chemo- and regioselective intermolecular decarboxylative addition of 尾-ketoacids to terminal allenes is reported. Using a Rh(I)/DPPF system, tertiary and quaternary carbon centers were formed with exclusively branched selectivity under mild conditions. Preliminary mechanism studies support that the carbon鈥揷arbon bond formation precedes the decarboxylation and the reaction occurs in an outer-sphere mechanism.