Diastereoselective and Enantioselective Synthesis of Unsymmetric β,β-Diaryl-α-Amino Acid Esters via Organocatalytic 1,6-Conjugate Addition of para-Quinone Methides
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- 作者：Xiang-Zhi Zhang ; Yu-Hua Deng ; Xu Yan ; Ke-Yin Yu ; Fang-Xin Wang ; Xiao-Yan Ma ; Chun-An Fan
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：July 1, 2016
- 年：2016
- 卷：81
- 期：13
- 页码：5655-5662
- 全文大小：567K
- 年卷期：0
- ISSN：1520-6904
文摘
A novel strategy based on phase transfer catalysis for the diastereoselective and enantioselective direct assembly of unsymmetric β,β-diaryl-α-amino acid esters via 1,6-conjugate addition of para-quinone methides and glycine derivatives is described. This protocol also provides an alternative route to the synthetically interesting functionalized chiral tetrahydroisoquinoline and its analogues.