Amphimedosides A鈥揅: Synthesis, Chemoselective Glycosylation, And Biological Evaluation

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• 作者：Joseph M. Langenhan ; Edouard Mullarky ; Derek K. Rogalsky ; James R. Rohlfing ; Anja E. Tjaden ; Halina M. Werner ; Leonardo M. Rozal ; Steven A. Loskot
• 刊名：The Journal of Organic Chemistry
• 出版年：2013
• 出版时间：February 15, 2013
• 年：2013
• 卷：78
• 期：4
• 页码：1670-1676
• 全文大小：331K
• 年卷期：v.78,no.4(February 15, 2013)
• ISSN：1520-6904

文摘

The amphimedosides, discovered in 2006, are the first examples of naturally occurring glycosylated alkoxyamines. We report syntheses of amphimedosides A鈥揅 that feature a stereoselective oxyamine neoglycosylation and found that these alkaloids display modest cytotoxicity toward seven diverse human cancer cell lines, exhibiting IC₅₀ values ranging from 3.0 渭M to greater than 100 渭M.