An Alternate Route to 2-Amino-3-nitro-5-bromo-4-picoline: Regioselective Pyridine Synthesis via 2-Nitramino-picoline Intermediate

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• 作者：Apurba Bhattacharya ; Vikram C. Purohit ; Prashant Deshpande ; Annie Pullockaran ; John A. Grosso ; John D. DiMarco ; Jack Z. Gougoutas
• 刊名：Organic Process Research & Development
• 出版年：2007
• 出版时间：September 2007
• 年：2007
• 卷：11
• 期：5
• 页码：885 - 888
• 全文大小：198K
• 年卷期：v.11,no.5(September 2007)
• ISSN：1520-586X

文摘

The 2-nitramino functionality in 2-nitramino-4-picoline was successfully exploited not only as a protecting group but also as a directional handle to afford an efficient, atom-economic, and regioselective synthesis of 2-amino-5-bromo-3-nitro-4-picoline (4), a precursor for a drug candidate in development.