Radical Departure: Thermally-Triggered Degradation of Azo-Containing Poly(β-thioester)s

详细信息    查看全文

• 作者：Hao Sun ; Daniel J. Dobbins ; Yuqiong Dai ; Christopher P. Kabb ; Shijian Wu ; Jawaher A. Alfurhood ; Carlos Rinaldi ; Brent S. Sumerlin
• 刊名：ACS Macro Letters
• 出版年：2016
• 出版时间：June 21, 2016
• 年：2016
• 卷：5
• 期：6
• 页码：688-693
• 全文大小：443K
• 年卷期：0
• ISSN：2161-1653

文摘

The design and synthesis of a new class of thermally-labile poly(β-thioester)s is reported. Aliphatic azo linkages were incorporated into the main chain of the polymers to allow for degradation to lower molecular weights upon heating. These polymers displayed a temperature-dependent degradation profile with a significant increase in decomposition rate as the temperature was raised from 60 to 95 °C. This approach was further extended to prepare amphiphilic triblock copolymers containing poly(β-thioester)s and poly(ethylene glycol) (PEG). The resulting block copolymers were capable of self-assembly into micelles in water. Moreover, the assembled nanoparticles underwent dissociation as a result of exposure to heat.