Fabrication of Multifunctional Layer-by-Layer Nanocapsules toward the Design of Theragnostic Nanoplatform
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- 作者：Hee-Jae Yoon ; Tae Geuk Lim ; Joo-Ho Kim ; Young Min Cho ; Yong Seok Kim ; Ui Seok Chung ; Jung Hyun Kim ; Byoung Wook Choi ; Won-Gun Koh ; Woo-Dong Jang
- 刊名：Biomacromolecules
- 出版年：2014
- 出版时间：April 14, 2014
- 年：2014
- 卷：15
- 期：4
- 页码：1382-1389
- 全文大小：491K
- 年卷期：v.15,no.4(April 14, 2014)
- ISSN：1526-4602
文摘
Self-assembled polymeric nanocapsules (NCs) that incorporate dendrimer porphyrin (DP) in the shells and superparamagnetic iron oxide nanoparticles (SPIONs) in the cores are fabricated to create a theragnostic platform for the application in photodynamic therapy (PDT) and magnetic resonance imaging (MRI). SPIONs-embedded polystyrene NPs (SPIONs@PS) are used as a template to build up multilayered NCs. The formation of PAH/DP multilayer on the SPIONs@PS is monitored by zeta-pential and fluorescence emission measurement, because the porphyrin unit in the core of DP has strong red fluorescence emission. NCs have strong enough magnetic property (>20 emu/g) for MRI application with typical superparamagnetic behavior, where the linear correlation of R2 and Fe concentration at diluted conditions led to corresponding T2 relaxivity coefficient (r2) value of 93.5 mM鈥? s鈥?. Cell viability study upon light irradiation reveals that NCs can successfully work in photosensitizer formulation for PDT.