Synthesis of Substituted Coumarins via Br酶nsted Acid Mediated Condensation of Allenes with Substituted Phenols or Anisoles

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• 作者：Sundae Kim ; Dongjin Kang ; Chang-Hee Lee ; Phil Ho Lee
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：August 3, 2012
• 年：2012
• 卷：77
• 期：15
• 页码：6530-6537
• 全文大小：411K
• 年卷期：v.77,no.15(August 3, 2012)
• ISSN：1520-6904

文摘

Coumarins were obtained from the condensation of electron-rich arenes with allenes in the presence of TfOH in good yield. Depending on the substituent pattern of allenes employed, the general synthetic method of 4-substituted and 3,4-disubstituted 3-arylcoumarins has been developed. Readily available allenes were employed as the three-carbon atom sources constituting the coumarin skeleton.