Photoresponsive Molecular Switch for Regulating Transmembrane Proton-Transfer Kinetics

详细信息    查看全文

• 作者：Ying Li ; Edmund C. M. Tse ; Christopher J. Barile ; Andrew A. Gewirth ; Steven C. Zimmerman
• 刊名：Journal of the American Chemical Society
• 出版年：2015
• 出版时间：November 11, 2015
• 年：2015
• 卷：137
• 期：44
• 页码：14059-14062
• 全文大小：324K
• ISSN：1520-5126

文摘

To control proton delivery across biological membranes, we synthesized a photoresponsive molecular switch and incorporated it in a lipid layer. This proton gate was reversibly activated with 390 nm light (Z-isomer) and then deactivated by 360 nm irradiation (E-isomer). In a lipid layer this stimuli responsive proton gate allowed the regulation of proton flux with irradiation to a lipid-buried O₂ reduction electrocatalyst. Thus, the catalyst was turned on and off with the E-to-Z interconversion. This light-induced membrane proton delivery system may be useful in developing any functional device that performs proton-coupled electron-transfer reactions.