Stereoselective Glycosylation of 2-Nitrogalactals Catalyzed by a Bifunctional Organocatalyst
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- 作者：Sandra Medina ; Matthew J. Harper ; Edward I. Balmond ; Silvia Miranda ; Giacomo E. M. Crisenza ; Diane M. Coe ; Eoghan M. McGarrigle ; M. Carmen Galan
- 刊名：Organic Letters
- 出版年：2016
- 出版时间：September 2, 2016
- 年：2016
- 卷：18
- 期：17
- 页码：4222-4225
- 全文大小：367K
- 年卷期：0
- ISSN：1523-7052
文摘
The use of a bifunctional cinchona/thiourea organocatalyst for the direct and α-stereoselective glycosylation of 2-nitrogalactals is demonstrated for the first time. The conditions are mild, practical, and applicable to a wide range of glycoside acceptors with products being isolated in good to excellent yields. The method is exemplified in the synthesis of mucin type Core 6 and 7 glycopeptides.