Formal Substitution of Bromocyclopropanes with Nitrogen Nucleophiles
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- 作者：Joseph E. Banning ; Jacob Gentillon ; Pavel G. Ryabchuk ; Anthony R. Prosser ; Andrew Rogers ; Andrew Edwards ; Andrew Holtzen ; Ivan A. Babkov ; Marina Rubina ; Michael Rubin
- 刊名：The Journal of Organic Chemistry
- 出版年：2013
- 出版时间：August 2, 2013
- 年：2013
- 卷：78
- 期：15
- 页码：7601-7616
- 全文大小：603K
- 年卷期：v.78,no.15(August 2, 2013)
- ISSN：1520-6904
文摘
A highly chemo- and diastereoselective protocol toward amino-substituted donor鈥揳cceptor cyclopropanes via the formal nucleophilic displacement in bromocyclopropanes is described. A wide range of N-nucleophiles, including carboxamides, sulfonamides, azoles, and anilines, can be efficiently employed in this transformation, providing expeditious access to stereochemically defined and densely functionalized cyclopropylamine derivatives.