Synthesis of Extended, 蟺-Conjugated Isoindolin-1-ones

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• 作者：Alex Bubar ; Paula Estey ; Michael Lawson ; Sara Eisler
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：February 3, 2012
• 年：2012
• 卷：77
• 期：3
• 页码：1572-1578
• 全文大小：332K
• 年卷期：v.77,no.3(February 3, 2012)
• ISSN：1520-6904

文摘

The synthesis and characterization of extended, conjugated molecules containing isoindolinone units was explored. Nucleophilic cyclizations between an amide and an alkyne were found to be an efficient method of producing the desired isoindolin-1-ones in high yields. A variety of derivatives were synthesized, demonstrating that a number of structural alterations could be made while maintaining good regio- and stereospecificity in the cyclized product.