Expeditious Synthesis of Phenanthridines from Benzylamines via Dual Palladium Catalysis
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- 作者：Giovanni Maestri ; Marie-Hlne Larraufie ; tienne Derat ; Cyril Ollivier ; Louis Fensterbank ; Emmanuel Lacte ; Max Malacria
- 刊名：Organic Letters
- 出版年：2010
- 出版时间：December 17, 2010
- 年：2010
- 卷：12
- 期：24
- 页码：5692-5695
- 全文大小：245K
- 年卷期：v.12,no.24(December 17, 2010)
- ISSN：1523-7052
文摘
A method for the synthesis of phenanthridines from benzylamines and aryl iodides which uses a dual palladium-catalyzed process is developed. The domino sequence ends via an intramolecular amination and an oxidative dehydrogenation. No protecting group or prefunctionalization of the amine is required, and the process uses dioxygen as the terminal oxidant.