Peptidolipins B鈥揊, Antibacterial Lipopeptides from an Ascidian-Derived Nocardia sp.
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- 作者：Thomas P. Wyche ; Yanpeng Hou ; Emmanuel Vazquez-Rivera ; Doug Braun ; Tim S. Bugni
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：April 27, 2012
- 年：2012
- 卷：75
- 期：4
- 页码：735-740
- 全文大小：281K
- 年卷期：v.75,no.4(April 27, 2012)
- ISSN：1520-6025
文摘
A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B鈥揊 (1鈥?b>5), which show distinct similarities to the previously reported l-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey鈥檚 method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.