A Photostable AIE Luminogen for Specific Mitochondrial Imaging and Tracking
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- 作者：Chris Wai Tung Leung ; Yuning Hong ; Sijie Chen ; Engui Zhao ; Jacky Wing Yip Lam ; Ben Zhong Tang
- 刊名：The Journal of the American Chemical Society
- 出版年：2013
- 出版时间：January 9, 2013
- 年：2013
- 卷：135
- 期：1
- 页码：62-65
- 全文大小：231K
- 年卷期：v.135,no.1(January 9, 2013)
- ISSN：1520-5126
文摘
Tracking the dynamics of mitochondrial morphology has attracted much research interest because of its involvement in early stage apoptosis and degenerative conditions. To follow this process, highly specific and photostable fluorescent probes are in demand. Commercially available mitochondria trackers, however, suffer from poor photostability. To overcome this limitation, we have designed and synthesized a fluorescent agent, tetraphenylethene-triphenylphosphonium (TPE-TPP), for mitochondrial imaging. Inherent from the mitochondrial-targeting ability of TPP groups and the aggregation-induced emission (AIE) characteristics of the TPE core, TPE-TPP possesses high specificity to mitochondria, superior photostability, and appreciable tolerance to environmental change, allowing imaging and tracking of the mitochondrial morphological changes in a long period of time.