Half-Antibody Functionalized Lipid−Polymer Hybrid Nanoparticles for Targeted Drug Delivery to Carcinoembryonic Antigen Presenting Pancreatic Cancer Cells
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- 作者：Che-Ming Jack Hu ; Sharmeela Kaushal ; Hop S. Tran Cao ; Santosh Aryal ; Marta Sartor ; Sadik Esener ; Michael Bouvet ; Liangfang Zhang
- 刊名：Molecular Pharmaceutics
- 出版年：2010
- 出版时间：June 7, 2010
- 年：2010
- 卷：7
- 期：3
- 页码：914-920
- 全文大小：214K
- 年卷期：v.7,no.3(June 7, 2010)
- ISSN：1543-8392
文摘
Current chemotherapy regimens against pancreatic cancer are met with little success as poor tumor vascularization significantly limits the delivery of oncological drugs. High-dose targeted drug delivery, through which a drug delivery vehicle releases a large payload upon tumor localization, is thus a promising alternative strategy against this lethal disease. Herein, we synthesize anti-carcinoembryonic antigen (CEA) half-antibody conjugated lipid−polymer hybrid nanoparticles and characterize their ligand conjugation yields, physicochemical properties, and targeting ability against pancreatic cancer cells. Under the same drug loading, the half-antibody targeted nanoparticles show enhanced cancer killing effect compared to the corresponding nontargeted nanoparticles.