Synthesis of Symmetric 1,4-Diamino-2-Butynes via a Cu(I)-Catalyzed One-Pot A3-Coupling/Decarboxylative Coupling of a Propiolic Acid, an Aldehyde, and an Amine

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• 作者：Huangdi Feng ; Denis S. Ermolat鈥檈v ; Gonghua Song ; Erik V. Van der Eycken
• 刊名：The Journal of Organic Chemistry
• 出版年：2012
• 出版时间：June 1, 2012
• 年：2012
• 卷：77
• 期：11
• 页码：5149-5154
• 全文大小：316K
• 年卷期：v.77,no.11(June 1, 2012)
• ISSN：1520-6904

文摘

A novel microwave-assisted approach for the one-pot Cu(I)-catalyzed A³-coupling/decarboxylative coupling (PA²-coupling) of a propiolic acid, an aldehyde, and an amine, resulting in the formation of diversely substituted 1,4-diamino-2-butynes,is described. It is noteworthy that this new multicomponent coupling provides an efficient access to introduce alkyl and aryl group at the 1,4-position of the 1,4-diamino-2-butynes.