Catalytic Arylsulfonyl Radical Triggered 1,7-Enyne Bicyclizations

详细信息    查看全文

• 作者：Yi-Long Zhu ; Bo Jiang ; Wen-Juan Hao ; Jiang-Kai Qiu ; Jun Sun ; De-Cai Wang ; Ping Wei ; Ai-Fang Wang ; Guigen Li ; Shu-Jiang Tu
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：December 18, 2015
• 年：2015
• 卷：17
• 期：24
• 页码：6078-6081
• 全文大小：407K
• ISSN：1523-7052

文摘

A new metal-free bicyclization reaction of 1,7-enynes anchored by 伪,尾-conjugates with arylsulfonyl radicals generated in situ from sulfonyl hydrazides has been established using tert-butyl hydroperoxide and tetrabutylammonium iodide. The reactions occurred through sulfonylation/6-exo-dig/6-exo-trig bicyclization/in situ desulfonylation/5-exo-trig cyclization/alkyl or alkenyl migration cascade mechanism to give benzo[j]phenanthridines regioselectively.