Enantioselective Construction of 3-Hydroxy Oxindoles via Decarboxylative Addition of 尾-Ketoacids to Isatins

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• 作者：Fangrui Zhong ; Weijun Yao ; Xiaowei Dou ; Yixin Lu
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：August 3, 2012
• 年：2012
• 卷：14
• 期：15
• 页码：4018-4021
• 全文大小：311K
• 年卷期：v.14,no.15(August 3, 2012)
• ISSN：1523-7052

文摘

The first highly enantioselective decarboxylative addition of 尾-ketoacids to isatins mediated by a bifunctional tertiary amine鈥搕hiourea catalyst has been developed, allowing facile synthesis of biologically important 3-hydroxy oxindoles in good yields and excellent enantioselectivities. The method reported represents a valuable approach of utilizing 尾-ketoacids as synthetic equivalents of aryl/alkyl methyl ketone enolates.