Synthesis and Herbicidal Evaluation of Novel 3-[(-Hydroxy-substituted)benzylidene]pyrrolidine-2,4-diones
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- 作者：Youquan Zhu ; Xiaomao Zou ; Fangzhong Hu ; Changsheng Yao ; Bin Liu ; and Huazheng Yang
- 刊名：Journal of Agricultural and Food Chemistry
- 出版年：2005
- 出版时间：November 30, 2005
- 年：2005
- 卷：53
- 期：24
- 页码：9566 - 9570
- 全文大小：69K
- 年卷期：v.53,no.24(November 30, 2005)
- ISSN：1520-5118
文摘
A series of 3-[(
-hydroxy-substituted) benzylidene]pyrrolidine-2,4-dione derivatives were synthesizedas candidate herbicides by reacting different aroyl acetates with N-substituted glycine esters. Thenew compounds were identified by 1H NMR spectroscopy and elemental analyses. Their herbicidalactivities were evaluated. Some compounds exhibited excellent herbicidal activities at a dose of 187.5g/ha. A suitable electron-donating substituent at the 2- and/or 4-position of the phenyl ring was essentialfor high herbicidal activity, a result that has not been reported before. It was also found that the titlecompound's structure-activity relationships were different from those of other similar kinds of earliercompounds, a result that may depend on the enol structure difference.Keywords: Herbicide; aroyl acetate; HPPD; electron-donating group; structure-activity relationship(SAR)
-hydroxy-substituted) benzylidene]pyrrolidine-2,4-dione derivatives were synthesizedas candidate herbicides by reacting different aroyl acetates with N-substituted glycine esters. Thenew compounds were identified by 1H NMR spectroscopy and elemental analyses. Their herbicidalactivities were evaluated. Some compounds exhibited excellent herbicidal activities at a dose of 187.5g/ha. A suitable electron-donating substituent at the 2- and/or 4-position of the phenyl ring was essentialfor high herbicidal activity, a result that has not been reported before. It was also found that the titlecompound's structure-activity relationships were different from those of other similar kinds of earliercompounds, a result that may depend on the enol structure difference.Keywords: Herbicide; aroyl acetate; HPPD; electron-donating group; structure-activity relationship(SAR)