CAPER: a Chromosome-Assembled human Proteome browsER
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- 作者：Feifei Guo ; Dan Wang ; Zhongyang Liu ; Liang Lu ; Wei Zhang ; Haiyan Sun ; Hongxing Zhang ; Jie Ma ; Songfeng Wu ; Ning Li ; Ying Jiang ; Weimin Zhu ; Jun Qin ; Ping Xu ; Dong Li ; Fuchu He
- 刊名：Journal of Proteome Research
- 出版年：2013
- 出版时间：January 4, 2013
- 年：2013
- 卷：12
- 期：1
- 页码：179-186
- 全文大小：588K
- 年卷期：v.12,no.1(January 4, 2013)
- ISSN：1535-3907
文摘
High-throughput mass spectrometry and antibody-based experiments have begun to produce a large amount of proteomic data sets. Chromosome-based visualization of these data sets and their annotations can help effectively integrate, organize, and analyze them. Therefore, we developed a web-based, user-friendly Chromosome-Assembled human Proteome browsER (CAPER). To display proteomic data sets and related annotations comprehensively, CAPER employs two distinct visualization strategies: track-view for the sequence/site information and the correspondence between proteome, transcriptome, genome, and chromosome and heatmap-view for the qualitative and quantitative functional annotations. CAPER supports data browsing at multiple scales through Google Map-like smooth navigation, zooming, and positioning with chromosomes as the reference coordinate. Both track-view and heatmap-view can mutually switch, providing a high-quality user interface. Taken together, CAPER will greatly facilitate the complete annotation and functional interpretation of the human genome by proteomic approaches, thereby making a significant contribution to the Chromosome-Centric Human Proteome Project and even the human physiology/pathology research. CAPER can be accessed at http://www.bprc.ac.cn/CAPE.