Quinazoline Synthesis via Rh(III)-Catalyzed Intermolecular C–H Functionalization of Benzimidates with Dioxazolones

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• 作者：Jie Wang ; Shanke Zha ; Kehao Chen ; Feifei Zhang ; Chao Song ; Jin Zhu
• 刊名：Organic Letters
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：18
• 期：9
• 页码：2062-2065
• 全文大小：408K
• 年卷期：0
• ISSN：1523-7052

文摘

An efficient double C–N bond formation sequence to prepare highly substituted quinazolines utilizing benzimidates and dioxazolones under the catalytic redox-neutral [Cp*RhCl₂]₂/AgBF₄ system, where dioxazolones could work as an internal oxidant to maintain the catalytic cycle, is reported. N-Unsubstituted imine not only acts as a directing group but also functions as a nucleophile in postcoupling cyclization, and dioxazolone acts as a coupling partner for access to heterocycle.