Olsalazine-Based Metal–Organic Frameworks as Biocompatible Platforms for H2 Adsorption and Drug Delivery

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• 作者：Dana J. Levine ; Tomče Runčevski ; Matthew T. Kapelewski ; Benjamin K. Keitz ; Julia Oktawiec ; Douglas A. Reed ; Jarad A. Mason ; Henry Z. H. Jiang ; Kristen A. Colwell ; Christina M. Legendre ; Stephen A. FitzGerald ; Jeffrey R. Long
• 刊名：Journal of the American Chemical Society
• 出版年：2016
• 出版时间：August 17, 2016
• 年：2016
• 卷：138
• 期：32
• 页码：10143-10150
• 全文大小：495K
• 年卷期：0
• ISSN：1520-5126

文摘

The drug olsalazine (H₄olz) was employed as a ligand to synthesize a new series of mesoporous metal–organic frameworks that are expanded analogues of the well-known M₂(dobdc) materials (dobdc^4– = 2,5-dioxido-1,4-benzenedicarboxylate; M-MOF-74). The M₂(olz) frameworks (M = Mg, Fe, Co, Ni, and Zn) exhibit high surface areas with large hexagonal pore apertures that are approximately 27 Å in diameter. Variable temperature H₂ adsorption isotherms revealed strong adsorption at the open metal sites, and in situ infrared spectroscopy experiments on Mg₂(olz) and Ni₂(olz) were used to determine site-specific H₂ binding enthalpies. In addition to its capabilities for gas sorption, the highly biocompatible Mg₂(olz) framework was also evaluated as a platform for the delivery of olsalazine and other encapsulated therapeutics. The Mg₂(olz) material (86 wt % olsalazine) was shown to release the therapeutic linker through dissolution of the framework under simulated physiological conditions. Furthermore, Mg₂(olz) was used to encapsulate phenethylamine (PEA), a model drug for a broad class of bioactive compounds. Under simulated physiological conditions, Mg₂(olz)(PEA)₂ disassembled to release PEA from the pores and olsalazine from the framework itself, demonstrating that multiple therapeutic components can be delivered together at different rates. The low toxicity, high surface areas, and coordinatively unsaturated metal sites make these M₂(olz) materials promising for a range of potential applications, including drug delivery in the treatment of gastrointestinal diseases.