Bifunctional Chelating Agents Based on Ionic Carbosilane Dendrons with DO3A at the Focal Point and Their Complexation Behavior with Copper(II)

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• 作者：Silvia Moreno ; Paula Ortega ; Francisco Javier de la Mata ; Maria Francesca. Ottaviani ; Michela Cangiotti ; Alberto Fattori ; Mar铆a 脕ngeles Mu帽oz-Fern谩ndez ; Rafael G贸mez
• 刊名：Inorganic Chemistry
• 出版年：2015
• 出版时间：September 21, 2015
• 年：2015
• 卷：54
• 期：18
• 页码：8943-8956
• 全文大小：682K
• ISSN：1520-510X

文摘

A synthetic protocol has been designed to incorporate the DO3A ligand to the focal point of cationic or anionic carbosilane dendrons, affording a set of bifunctional chelating agents (BFCAs) useful for potential biomedical applications. The complexation behavior study of ionic BFCAs has been accomplished by UV鈥搗is and electron paramagnetic resonance spectroscopy as well as potentiometric titrations. The presence of the dendron branches modifies the complexation capacity of the macrocyclic ring with respect to that of the 1,4,7,10-tetraazacyclodocecane-N,N鈥?N鈥?N鈥?tetraacetic acid (DOTA) ligand. Also, a different behavior has been observed in the carboxylate-terminated dendrons against analogous sulfonate- or amine-terminated dendrons in the contribution of the branches and peripheral groups to the coordination modes. The presence or not of Cu鈥揝₂O₂ coordination sites and the generation can be important factors to take into account for considering a particular biomedical application.