Diastereoselective Synthesis of 伪-Quaternary Aziridine-2-carboxylates via Aza-Corey鈥揅haykovsky Aziridination of N-tert-Butanesulfinyl Ketimino Esters

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• 作者：Maurice A. Marsini ; Jonathan T. Reeves ; Jean-Nicolas Desrosiers ; Melissa A. Herbage ; Jolaine Savoie ; Zhibin Li ; Keith R. Fandrick ; C. Avery Sader ; Bryan McKibben ; Donghong A. Gao ; Jianwen Cui ; Nina C. Gonnella ; Heewon Lee ; Xudong Wei ; Frank Roschangar ; Bruce Z. Lu ; Chris H. Senanayake
• 刊名：Organic Letters
• 出版年：2015
• 出版时间：November 20, 2015
• 年：2015
• 卷：17
• 期：22
• 页码：5614-5617
• 全文大小：414K
• ISSN：1523-7052

文摘

A general, scalable, and highly diastereoselective aziridination of N-tert-butanesulfinyl ketimino esters is described. The methodology has been utilized to provide straightforward access to previously unobtainable, biologically relevant 伪-quaternary amino esters and derivatives starting from readily available precursors.