Peroxide-Mediated Transition-Metal-Free Direct Amidation of Alcohols with Nitroarenes

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• 作者：Fuhong Xiao ; Yong Liu ; Chenglin Tang ; Guo-Jun Deng
• 刊名：Organic Letters
• 出版年：2012
• 出版时间：February 17, 2012
• 年：2012
• 卷：14
• 期：4
• 页码：984-987
• 全文大小：756K
• 年卷期：v.14,no.4(February 17, 2012)
• ISSN：1523-7052

文摘

An unusual direct amidation of alcohols with nitroarenes mediated by peroxides has been discovered. The reaction tolerated a wide range of functionalities, and various aromatic amides were obtained in moderate to good yields in the absence of transition-metal catalyst. The peroxides and solvents had a significant impact on the reaction yield.