Formal Total Synthesis of l-Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System

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• 作者：Shinsuke Inuki ; Keisuke Sato ; Takahide Fukuyama ; Ilhyong Ryu ; Yukari Fujimoto
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：82
• 期：2
• 页码：1248-1253
• 全文大小：405K
• ISSN：1520-6904

文摘

A formal total synthesis of an class="smallcaps">lan>-ossamine was achieved. The key feature of the synthesis was the decarboxylative functionalization of a threonine derivative using visible-light-mediated photoredox catalysis. This reaction was implemented in a flow reactor, allowing for the efficient conversion to the desired product.