Synthesis and Electrochemical and Biological Studies of Novel Coumarin鈥揅halcone Hybrid Compounds
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- 作者：Fernanda P茅rez-Cruz ; Saleta Vazquez-Rodriguez ; Maria Jo茫o Matos ; Alejandra Herrera-Morales ; Frederick A. Villamena ; Amlan Das ; Bhavani Gopalakrishnan ; Claudio Olea-Azar ; Lourdes Santana ; Eugenio Uriarte
- 刊名：Journal of Medicinal Chemistry
- 出版年：2013
- 出版时间：August 8, 2013
- 年：2013
- 卷：56
- 期：15
- 页码：6136-6145
- 全文大小：398K
- 年卷期：v.56,no.15(August 8, 2013)
- ISSN：1520-4804
文摘
A series of novel hydroxy-coumarin鈥揷halcone hybrid compounds 2a鈥?b>i has been synthesized by employing a simple and efficient methodology. An electrochemical characterization using cyclic voltammetry and ESR spectroscopy were carried out to characterize the oxidation mechanism for the target compounds. The antioxidant capacity and reactivity were determined by ORAC and ESR assays, respectively. Biological assays were assessed to evaluate the cytotoxicity and cytoprotection capacity against ROS/RNS on BAEC. The results revealed that all tested compounds present ORAC values that are much higher than other well-known antioxidant compounds such as quercetin and catechin. Compound 2e showed the highest ORAC value (14.1) and also presented a low oxidation potential, good scavenging capacity against hydroxyl radicals, low cytotoxicity, and high cytoprotective activity.