Measuring Biological Age via Metabonomics: The Metabolic Age Score

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• 作者：Johannes Hertel ; Nele Friedrich ; Katharina Wittfeld ; Maik Pietzner ; Kathrin Budde ; Sandra Van der Auwera ; Tobias Lohmann ; Alexander Teumer ; Henry V?lzke ; Matthias Nauck ; Hans J?rgen Grabe
• 刊名：Journal of Proteome Research
• 出版年：2016
• 出版时间：February 5, 2016
• 年：2016
• 卷：15
• 期：2
• 页码：400-410
• 全文大小：343K
• ISSN：1535-3907

文摘

Chronological age is one of the most important risk factors for adverse clinical outcome. Still, two individuals at the same chronological age could have different biological aging states, leading to different individual risk profiles. Capturing this individual variance could constitute an even more powerful predictor enhancing prediction in age-related morbidity. Applying a nonlinear regression technique, we constructed a metabonomic measurement for biological age, the metabolic age score, based on urine data measured via ¹H NMR spectroscopy. We validated the score in two large independent population-based samples by revealing its significant associations with chronological age and age-related clinical phenotypes as well as its independent predictive value for survival over approximately 13 years of follow-up. Furthermore, the metabolic age score was prognostic for weight loss in a sample of individuals who underwent bariatric surgery. We conclude that the metabolic age score is an informative measurement of biological age with possible applications in personalized medicine.