Septocylindrins A and B: Peptaibols Produced by the Terrestrial Fungus Septocylindrium sp. LL-Z1518

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• 作者：Mia Y. Summers ; Fangming Kong ; Xidong Feng ; Marshall M. Siegel ; Jeffrey E. Janso ; Edmund I. Graziani ; Guy T. Carter
• 刊名：Journal of Natural Products
• 出版年：2007
• 出版时间：March 2007
• 年：2007
• 卷：70
• 期：3
• 页码：391 - 396
• 全文大小：113K
• 年卷期：v.70,no.3(March 2007)
• ISSN：1520-6025

文摘

Two new peptaibols, septocylindrin A (1) and septocylindrin B (2), related to the well-studied membrane-channel-forming peptaibol alamethicin, were obtained from a terrestrial isolate of the fungus Septocylindrium sp. Both 1 and 2are linear 19-amino acid peptides with a modified phenylalanine C-terminus. Analysis of the HRMS data indicated thatthey differ only in the 18th residue, where 1 contains Glu and 2 contains Gln. The structures of these two peptaibolswere determined by extensive NMR and HRMS analysis. The absolute configurations of amino acids present in 1 weredetermined using Marfey's methodology. Both compounds were isolated through bioassay-guided fractionation andexhibited significant antibacterial and antifungal activity.