Copper-Mediated 伪-Trifluoromethylation of N-Phenylcinnamamides Coupled with Dearomatization: Access to Trifluoromethylated 1-Azaspiro[4.5]decanes

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• 作者：Guifang Han ; Qiang Wang ; Yuxiu Liu ; Qingmin Wang
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：November 21, 2014
• 年：2014
• 卷：16
• 期：22
• 页码：5914-5917
• 全文大小：354K
• ISSN：1523-7052

文摘

Copper-mediated intramolecular trifluoromethylation of N-phenylcinnamamides coupled with cyclization and dearomatization was used to construct various trifluoromethylated 1-azaspiro[4.5]decanes in moderate to high yields and with excellent regioselectivity and diastereoselectivity.