Regioselective Synthesis of Novel Spiropyrrolidines and Spirothiapyrrolizidines Through Multicomponent 1,3-Dipolar Cycloaddition Reaction of Azomethine Ylides

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• 作者：Hai Liu ; Guolan Dou ; Daqing Shi
• 刊名：Journal of Combinatorial Chemistry
• 出版年：2010
• 出版时间：September 13, 2010
• 年：2010
• 卷：12
• 期：5
• 页码：633-637
• 全文大小：228K
• 年卷期：v.12,no.5(September 13, 2010)
• ISSN：1520-4774

文摘

A series of novel spiropyrrolidines and spirothiapyrrolizidines were synthesized via a three-component 1,3-dipolar cycloaddition reaction of isatin or acenaphthenequinone, sarcosine or thiaproline and 4-hydroxy-6-methyl-3-((E)-3-phenylacryloyl)-2H-pyran-2-ones in refluxing ethanol. Advantages of this method include the availability of starting materials, mild reaction conditions, high yields, and the complete regioselectivity observed.