Palladium-Catalyzed Intermolecular Aerobic Oxidative Cyclization of 2-Ethynylanilines with Isocyanides: Regioselective Synthesis of 4-Halo-2-aminoquinolines

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• 作者：Bifu Liu ; Hanling Gao ; Yue Yu ; Wanqing Wu ; Huanfeng Jiang
• 刊名：Journal of Organic Chemistry
• 出版年：2013
• 出版时间：October 18, 2013
• 年：2013
• 卷：78
• 期：20
• 页码：10319-10328
• 全文大小：447K
• 年卷期：v.78,no.20(October 18, 2013)
• ISSN：1520-6904

文摘

A robust and regioselective palladium-catalyzed intermolecular aerobic oxidative cyclization of 2-ethynylanilines with isocyanides to the synthesis of 4-halo-2-aminoquinolines is reported herein. The procedure constructs various 4-halo-2-aminoquinolines with moderate to excellent yields (47鈥?4%) and broad substrates scope. Furthermore, this process can be easily extended to synthesis of various 6H-indolo[2,3-b]quinolines via an intramolecular Buchwald鈥揌artwig cross-coupling reaction in two-step one-pot manner.