Scale-Up of Organic Reactions in a Pharmaceutical Kilo-Lab Using a Commercial Microwave Reactor

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• 作者：Hansjoerg Lehmann ; Luigi LaVecchia
• 刊名：Organic Process Research & Development
• 出版年：2010
• 出版时间：May 21, 2010
• 年：2010
• 卷：14
• 期：3
• 页码：650-656
• 全文大小：141K
• 年卷期：v.14,no.3(May 21, 2010)
• ISSN：1520-586X

文摘

A range of pharmaceutically relevant reactions were investigated for scale-up in a kilo-lab environment using a commercial batch microwave reactor. Typical scale-up issues are discussed, taking into account the specific limitations of microwave heating in large-scale experiments. Examples of scale-up from 15 mL to 1 L are presented and demonstrate that the synthesis of compounds on greater than 100 g scale is feasible in one batch. Aided by this new technology reaction times have been significantly reduced and the productivity of our scale-up laboratory has been enhanced. Production rates of several hundred grams per day were achieved using microwave technology. The article concludes with a brief discussion of advantages and disadvantages of this type of batch microwave reactor.