Phenanthrene Derivatives from Cymbidium Great Flower Marie Laurencin and Their Biological Activities

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• 作者：Kazuko Yoshikawa ; Takuya Ito ; Kanako Iseki ; Chihiro Baba ; Hiroshi Imagawa ; Yasuyuki Yagi ; Hiroshi Morita ; Yoshinori Asakawa ; Sachiko Kawano ; Toshihiro Hashimoto
• 刊名：Journal of Natural Products
• 出版年：2012
• 出版时间：April 27, 2012
• 年：2012
• 卷：75
• 期：4
• 页码：605-609
• 全文大小：295K
• 年卷期：v.75,no.4(April 27, 2012)
• ISSN：1520-6025

文摘

A new phenanthrendione, ephemeranthoquinone B (1), two phenanthrenes, marylaurencinols A (2) and B (3), and a phenanthrene glucoside, marylaurencinoside A (4), were isolated from the roots of Cymbidium Great Flower Marie Laurencin, along with six known phenanthrenes, 5鈥?b>10. The structures of these compounds were established by a combination of extensive NMR spectroscopy and/or X-ray crystallographic analysis and chemical degradation. The compounds were tested for antibacterial activities against Bacillus subtilis and Klebsiella pneumoniae and for cytotoxic activity against the human promyelocytic leukemia (HL-60) cell line. Compounds 1, 3, and 6 showed antibacterial activities with minimum inhibitory concentration (MIC) values in the range of 4.88 to 65.10 渭M. Notably, ephemeranthoquinone B (1) had a strong antibacterial effect on B. subtilis. Furthermore, 1 exhibited moderate cytotoxic activity (IC₅₀ 2.8 渭M) against HL-60 cells. Compounds 4鈥?b>9 also showed weak cytotoxic activity against the HL-60 cell line with IC₅₀ values of 19.3鈥?2.4 渭M.