Emerging Use of Isotope Ratio Mass Spectrometry as a Tool for Discrimination of 3,4-Methylenedioxymethamphetamine by Synthetic Route

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• 作者：Hilary A. S. Buchanan ; Niamh Nic Daé ; id ; Wolfram Meier-Augenstein ; Helen F. Kemp ; William J. Kerr ; Michael Middleditch
• 刊名：Analytical Chemistry
• 出版年：2008
• 出版时间：May 1, 2008
• 年：2008
• 卷：80
• 期：9
• 页码：3350 - 3356
• 全文大小：137K
• 年卷期：v.80,no.9(May 1, 2008)
• ISSN：1520-6882

文摘

Drug profiling, or the ability to link batches of illicit drugsto a common source or synthetic route, has long been agoal of law enforcement agencies. Research in the pastdecade has explored drug profiling with isotope ratio massspectrometry (IRMS). This type of research can be limitedby the use of substances seized by police, of which theprovenance is unknown. Fortunately, however, somestudies in recent years have been carried out on drugssynthesized in-house and therefore of known history. Inthis study, 18 MDMA samples were synthesized in-housefrom aliquots of the same precursor by three commonreductive amination routes and analyzed for ¹³C, ¹⁵N, and²H isotope abundance using IRMS. For these threepreparative methods, results indicate that ²H isotopeabundance data is necessary for discrimination by synthetic route. Furthermore, hierarchical cluster analysisusing ²H data on its own or combined with ¹³C and/or¹⁵N provides a statistical means for accurate discrimination by synthetic route.