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Abyssomicin E (
1), a new polycyclic metabolite with a C19 skeleton, was isolated from
Streptomyces sp. (HKI0381). Its chemical structure wasdetermined by comprehensive NMR and MS spectroscopic analyses. For the first time in this recently discovered class of compounds, theabsolute stereochemistry was directly established by subsequent sin
gle-crystal X-ray diffraction study usin
g anomalous dispersion with copperradiation.