Mechanistic Basis for Regioselection and Regiodivergence in Nickel-Catalyzed Reductive Couplings

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• 作者：Evan P. Jackson ; Hasnain A. Malik ; Grant J. Sormunen ; Ryan D. Baxter ; Peng Liu ; Hengbin Wang ; Abdur-Rafay Shareef ; John Montgomery
• 刊名：Accounts of Chemical Research
• 出版年：2015
• 出版时间：June 16, 2015
• 年：2015
• 卷：48
• 期：6
• 页码：1736-1745
• 全文大小：532K
• ISSN：1520-4898

文摘

The control of regiochemistry is a considerable challenge in the development of a wide array of catalytic processes. Simple 蟺-components such as alkenes, alkynes, 1,3-dienes, and allenes are among the many classes of substrates that present complexities in regioselective catalysis. Considering an internal alkyne as a representative example, when steric and electronic differences between the two substituents are minimal, differentiating among the two termini of the alkyne presents a great challenge. In cases where the differences between the alkyne substituents are substantial, overcoming those biases to access the regioisomer opposite that favored by substrate biases often presents an even greater challenge.