Kandenols A鈥揈, Eudesmenes from an Endophytic Streptomyces sp. of the Mangrove Tree Kandelia candel
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- 作者：Ling Ding ; Armin Maier ; Heinz-Herbert Fiebig ; Wen-Han Lin ; Gundela Peschel ; Christian Hertweck
- 刊名：Journal of Natural Products
- 出版年：2012
- 出版时间：December 28, 2012
- 年：2012
- 卷：75
- 期：12
- 页码：2223-2227
- 全文大小：253K
- 年卷期：v.75,no.12(December 28, 2012)
- ISSN：1520-6025
文摘
Five novel eudesmene-type sesquiterpenes, kandenols A鈥揈 (1鈥?b>5), have been isolated from Streptomyces sp. HKI0595 derived from the mangrove plant Kandelia candel. Their structures were established through NMR and mass spectrometry, and absolute configurations were established by the Mosher method and comparison of CD spectra with 伪-rotunol and 尾-rotunol. The kandenols are reminiscent of various plant-derived eudesmenes, yet kandenols B and C are unusual because of their hydroperoxide moieties. Kandenol E is the first bacterial agarofuran, which belongs to an important group of antibiotics. Whereas the kandenols display no cytotoxicity against 12 human cell lines, weak to moderate antimicrobial activities were detected against Bacillus subtilis ATCC 6633 and Mycobacterium vaccae IMET 10670.