Gold(I)-Catalyzed Synthesis of Optically Active 1,4-Oxazepan-7-ones

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• 作者：Akio Kamimura ; Yu Yamane ; Ryuichiro Yo ; Toshiyuki Tanaka ; Hidemitsu Uno
• 刊名：Journal of Organic Chemistry
• 出版年：2014
• 出版时间：August 15, 2014
• 年：2014
• 卷：79
• 期：16
• 页码：7696-7702
• 全文大小：335K
• ISSN：1520-6904

文摘

Optically active seven-membered lactones, dimethyleneoxazepanones, were readily prepared in good yields from chiral 尾-(N-propargylic)amino-伪-methylene carboxylic acid tert-butyl esters in the presence of catalytic amounts of Ph₃PAuCl and Cu(OTf)₂. A smooth 7-exo-dig cyclization was observed.