Mode of Action of Novel 2-(Benzylamino)-4-methyl-6-(trifluoro- methyl)-1,3,5-triazine Herbicides: Inhibition of Photosynthetic Electron Transport and Binding Studies

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• 作者：Aiko Ohki ; Nobuhiro Kuboyama ; Kazuya Koizumi ; Akira Tanaka ; Yukiharu Sato ; Hitoshi Kohno ; Peter Bö ; ger ; and Ko Wakabayashi
• 刊名：Journal of Agricultural and Food Chemistry
• 出版年：1999
• 出版时间：October 1999
• 年：1999
• 卷：47
• 期：10
• 页码：4398 - 4402
• 全文大小：144K
• 年卷期：v.47,no.10(October 1999)
• ISSN：1520-5118

文摘

Novel 2-(benzylamino)-4-methyl-6-(trifluoromethyl)-1,3,5-triazines have the same 1,3,5-triazineskeleton as atrazine, although some of them, for example, 2-(3-chlorobenzylamino)-4-methyl-6-(trifluoromethyl)-1,3,5-triazine [pI₅₀(spinach) = 7.21], show a >3 times stronger photosyntheticelectron transport inhibitory activity than atrazine [pI₅₀(spinach) = 6.72]. The new triazines haveonly one amino group at the triazine ring, and their molecular shapes are different from atrazine.The replacement of the bound [¹⁴C]atrazine by 1,3,5-triazines was tested to determine whether thenovel 1,3,5-triazine analogues exhibit the same binding pattern at the D1-protein as atrazine. Itwas found that [¹⁴C]atrazine bound to the D1-protein was replaced by the triazine tested by a clearlycompetitive interaction. Obviously, the novel 1,3,5-triazines are attached to the same binding nicheas atrazine.Keywords: (Benzylamino)-1,3,5-triazines; D1-protein; binding partners; replacement; atrazine-resistant Chenopodium