Development of a Palladium-Catalyzed Carbonylative Coupling Strategy to 1,4-Diketones

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• 作者：Hongfei Yin ; Dennis U. Nielsen ; Mette K. Johansen ; Anders T. Lindhardt ; Troels Skrydstrup
• 刊名：ACS Catalysis
• 出版年：2016
• 出版时间：May 6, 2016
• 年：2016
• 卷：6
• 期：5
• 页码：2982-2987
• 全文大小：475K
• 年卷期：0
• ISSN：2155-5435

文摘

We report on a three-component palladium-catalyzed coupling strategy for accessing a wide range of 1,4-diketones, which represent important precursors to heterocycles. Our method relies on a carbonylative Heck reaction employing substituted allylic alcohols, aryl iodides, and carbon monoxide. The reaction conditions are mild and do not require high CO pressure, and a wide functional group tolerance is revealed, providing the desired 1,4-diketones in moderate to good yields. Furthermore, the methodology is adaptable to the selective installment of ¹³C-carbon isotopes at either one or both of the carbonyl positions.