Lewis Acid Catalyzed Regiospecific Cross-Dehydrative Coupling Reaction of 2-Furylcarbinols with β-Keto Amides or 4-Hydroxycoumarins: A Route to Furyl Enols

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• 作者：Maozhong Miao ; Yi Luo ; Hongli Li ; Xin Xu ; Zhengkai Chen ; Jianfeng Xu ; Hongjun Ren
• 刊名：Journal of Organic Chemistry
• 出版年：2016
• 出版时间：June 17, 2016
• 年：2016
• 卷：81
• 期：12
• 页码：5228-5235
• 全文大小：481K
• 年卷期：0
• ISSN：1520-6904

文摘

Lewis acid catalyzed directly dehydrative carbon–carbon bond formation reaction of 2-furylcarbinols with β-keto amides provides a straightforward method for regioselective synthesis of (Z)-furyl enols. Moreover, this Lewis acid catalyzed cross-coupling reaction can be extended to an interesting heterocyclic version featuring a functionalized 3-furyl-4-hydroxycoumarin synthesis.