Nanoshell Magnetic Resonance Imaging Contrast Agents

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• 作者：Chia-Hao Su ; Hwo-Shuenn Sheu ; Chia-Yun Lin ; Chih-Chia Huang ; Yi-Wei Lo ; Ying-Chih Pu ; Jun-Cheng Weng ; Dar-Bin Shieh ; Jyh-Horng Chen ; Chen-Sheng Yeh
• 刊名：Journal of the American Chemical Society
• 出版年：2007
• 出版时间：February 21, 2007
• 年：2007
• 卷：129
• 期：7
• 页码：2139 - 2146
• 全文大小：431K
• 年卷期：v.129,no.7(February 21, 2007)
• ISSN：1520-5126

文摘

Nanocontrast agents have great potential in magnetic resonance (MR) molecular imagingapplications for clinical diagnosis. We synthesized Au₃Cu₁ (gold and copper) nanoshells that showed apromising MR contrast effect. For in vitro MR images, the large proton r₁ relaxivities brightened T₁-weightedimages. As for the proton-dephasing effect in T₂, Au₃Cu₁ lightened MR images at the low concentration of0.125 mg mL^-1 (3.84 × 10^-7 mM), and then the signal continuously decreased as the concentrationincreased. For in vivo MR imaging, Au₃Cu₁ nanocontrast agents enhanced the contrast of blood vesselsand suggested their potential use in MR angiography as blood-pool agents. We propose that (1) thecooperativity originating from the form of the nanoparticles and (2) the large surface area coordinated towater from their porous hollow morphology are important for efficient relaxivity. In a cytotoxicity and animalsurvival assay, Au₃Cu₁ nanocontrast agents showed a dose-dependent toxic effect: the viability rate ofexperimental mice reached 83% at a dose of 20 mg kg^-1 and as much as 100% at 2 mg kg^-1.